产品货号：
Z12662
中文名称：
c-Cbl/CBL抗体
英文名称：
Anti-c-Cbl/CBL Antibody
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-c-Cbl/CBL Antibody |
| 指标别名 | C CBL;CBL;CBL2;c-Cbl;Proto oncogene c Cbl;RING finger protein 55;RNF55 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IF,ELISA |
| 基因名称 | CBL |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Synthesized peptide derived from human Cbl around the non-phosphorylation site of Y774. |
| 计算分子量 | 100KD |
| 成分 | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| 纯化方式 | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | -20℃可保存1年，短期保存或频繁使用请置于4℃，可保存一个月，避免反复冻融。 |
| 背景资料 | CBL(Cbl proto-oncogene) is also known as C-CBL,RNF55,CBL2 and E3 ubiquitin protein ligase.CBL is mapped to chromosome 11q23.3-qter by molecular characterization of the breakpoints in 2 somatic cell hybrids.The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome.This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes(E2) to specific substrates.This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation.As such it functions as a negative regulator of many signal transduction pathways.This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia.Mutations in this gene are also the cause of Noonan syndrome-like disorder. |
| Uniprot ID | P22681 |
| 基因名全称 | E3 ubiquitin-protein ligase CBL |
| 蛋白名全称 | E3 ubiquitin-protein ligase CBL |
| 推荐稀释比 | WB 1:500～1:2000 IHC 1:100～1:300 IF 1:200～1:1000 ELISA 1:5000 |
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